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Carbapenemase-producing Enterobacterales

  • Gram-negative bacilli occurring naturally in the GI tract
  • Resistant to carbapenem antibiotics
  • Several different carbapenemases genes in CPE:
    • Imipenemase (IMP)
    • Klebsiella penumoniae carbapenemase (KPC)
    • New-Delhi metallo-β-lactamase (NDM)
    • Verona integron-encoded metallo-β-lactamase (VIM) and
    • Oxacillinases (OXA)
  • For Enterobacterales, IMP(-4) most commonly found in Victoria (28% of all cases)
  • Assumed to be colonised indefinitely

Carbapenemase-producing Enterobacterales

  • Surveillance officially established in Victoria in 2015, became notifiable in 2018
  • Since becoming notifiable, notifications have been steadily increasing

Modelling possible control

  • We know that healthcare is a network phenomenon
  • Need to understand if CPE+ patients are different to CPE- patients